› 6gon

X-ray diffraction
1.65Å resolution

Crystal Structure Of Sea Bream Transthyretin in complex with Perfluorooctanoic acid (PFOA). Crystallized in PEG

Released:
DOI: 10.2210/pdb6gon/pdb
PDB entry 6gon coloured by chain, front view.
PDB entry 6gon coloured by chain, side view.
PDB entry 6gon coloured by chain, top view.
Source organism: Sparus aurata
Primary publication:
Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals.
Zhang J, Grundström C, Brännström K, Iakovleva I, Lindberg M, Olofsson A, Andersson PL, Sauer-Eriksson AE
Environ Sci Technol 52 11865-11874 (2018)
PMID: 30226982

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192947 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 135 amino acids
Theoretical weight: 14.46 KDa
Source organism: Sparus aurata
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9PTT3 (Residues: 20-149; Coverage: 99%)
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand 8PF 2 x 8PF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 72.408Å b: 76.203Å c: 107.103Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.193
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors.
Guo et al. (2020)
1 other article