› 6gq2

X-ray diffraction
1.54Å resolution

Crystal Structure of the PSMalpha3 Peptide Mutant K12A Forming Cross-Alpha Amyloid-like Fibril

Released:
DOI: 10.2210/pdb6gq2/pdb
PDB entry 6gq2 coloured by chain, front view.
PDB entry 6gq2 coloured by chain, side view.
PDB entry 6gq2 coloured by chain, top view.
Source organism: Staphylococcus aureus RF122
Primary publication:
Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity.
Tayeb-Fligelman E, Salinas N, Tabachnikov O, Landau M
Structure 28 301-313.e6 (2020)
PMID: 31918959

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143165 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phenol-soluble modulin alpha 3 peptide Chain: A
Molecule details ›
Chain: A
Length: 22 amino acids
Theoretical weight: 2.55 KDa
Source organism: Staphylococcus aureus RF122
Expression system: Not provided
UniProt:
  • Canonical: P0C807 (Residues: 1-22; Coverage: 100%)
Gene names: SAB0401.2, psmA3
Sequence domains: Phenol-soluble modulin alpha peptide family

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: C2
Unit cell:
a: 52.94Å b: 13.15Å c: 25.97Å
α: 90° β: 112.26° γ: 90°
R-values:
R R work R free
0.207 0.203 0.236
Expression system: Not provided

Quick links

Citations

5 review citations

Antimicrobial and Amyloidogenic Activity of Peptides. Can Antimicrobial Peptides Be Used against SARS-CoV-2?
Kurpe et al. (2020)
4 more

1 mention without citation

Phenol-soluble modulins PSMα3 and PSMβ2 form nanotubes that are cross-α amyloids.
Kreutzberger et al. (2022)