› 6gr2

X-ray diffraction
2.49Å resolution

Structure of human galactokinase in complex with galactose and ADP

Released:
DOI: 10.2210/pdb6gr2/pdb
PDB entry 6gr2 coloured by chain, front view.
PDB entry 6gr2 coloured by chain, side view.
PDB entry 6gr2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bezerra GA, Mackinnon S, Williams E, Zhang M, Arrowsmith C, Edwards A, Bountra C, Lai K, Yue WW, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galactokinase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 399 amino acids
Theoretical weight: 43.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51570 (Residues: 2-392; Coverage: 100%)
Gene names: GALK, GALK1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GAL 8 x GAL
Ligand ADP 8 x ADP
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 78.217Å b: 110.32Å c: 118.234Å
α: 113.85° β: 102.26° γ: 101.29°
R-values:
R R work R free
0.223 0.221 0.256
Expression system: Escherichia coli

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