› 6gr9

X-ray diffraction
2.25Å resolution

Human AURKC INCENP complex bound to VX-680

Released:
DOI: 10.2210/pdb6gr9/pdb
PDB entry 6gr9 coloured by chain, front view.
PDB entry 6gr9 coloured by chain, side view.
PDB entry 6gr9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Abdul Azeez KR, Sorrell FJ, von Delft F, Bountra C, Knapp S, Edwards AM, Arrowsmith C, Elkins JM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192512 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aurora kinase C Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UQB9 (Residues: 36-305; Coverage: 87%)
Gene names: AIE2, AIK3, AIRK3, ARK3, AURKC, STK13
Sequence domains: Protein kinase domain
Structure domains:
Inner centromere protein Chain: B
Molecule details ›
Chain: B
Length: 70 amino acids
Theoretical weight: 8.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQS7 (Residues: 835-903; Coverage: 8%)
Gene name: INCENP
Sequence domains: Inner centromere protein, ARK binding region

Ligands and Environments

2 bound ligands:
Ligand VX6 1 x VX6
Ligand SO4 1 x SO4
2 modified residues:
Ligand TPO 2 x TPO
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3121
Unit cell:
a: 82.617Å b: 82.617Å c: 121Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.224
Expression system: Escherichia coli

Quick links