› 6h0e

X-ray diffraction
1.95Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210486 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1 Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 222 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1 Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 218 amino acids
Theoretical weight: 23.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chains: G, I, J, K
Molecule details ›
Chains: G, I, J, K
Length: 24 amino acids
Theoretical weight: 2.66 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P10637 (Residues: 698-721; Coverage: 3%)
Gene names: Mapt, Mtapt, Tau

Ligands and Environments

1 bound ligand:
Ligand GOL 5 x GOL
2 modified residues:
Ligand PCA 4 x PCA
Ligand SEP 8 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 107.551Å b: 95.502Å c: 108.317Å
α: 90° β: 112.64° γ: 90°
R-values:
R R work R free
0.223 0.222 0.285
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

4 review citations

Immunotherapies for Neurodegenerative Diseases.
Mortada et al. (2021)
3 more

1 mention without citation

Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.
van Ameijde et al. (2018)