› 6h41

X-ray diffraction
2.75Å resolution

Structure of the complex of the IL-5 inhibitory peptide AF17121 bound to the IL-5 receptor IL-5Ralpha

Released:
DOI: 10.2210/pdb6h41/pdb
PDB entry 6h41 coloured by chain, front view.
PDB entry 6h41 coloured by chain, side view.
PDB entry 6h41 coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.
Scheide-Noeth JP, Rosen M, Baumstark D, Dietz H, Mueller TD
J Mol Biol 431 714-731 (2019)
PMID: 30529748

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166807 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-5 receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01344 (Residues: 27-332; Coverage: 77%)
Gene names: IL5R, IL5RA
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins
VAL-ASP-GLU-CYS-TRP-ARG-ILE-ILE-ALA-SER-HIS-THR-TRP-PHE-CYS-ALA-GLU-GLU Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 2.2 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P6422
Unit cell:
a: 138.061Å b: 138.061Å c: 145.855Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.226
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

1 citations in other articles

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.
Lay et al. (2023)

1 mention without citation

A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex.
Huene et al. (2022)