› 6h97

X-ray diffraction
2.6Å resolution

AlbAT99V mutant , albicidin resistance protein

Released:
DOI: 10.2210/pdb6h97/pdb
PDB entry 6h97 coloured by chain, front view.
PDB entry 6h97 coloured by chain, side view.
PDB entry 6h97 coloured by chain, top view.
Source organism: Klebsiella oxytoca
Primary publication:
Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA.
Sikandar A, Cirnski K, Testolin G, Volz C, Brönstrup M, Kalinina OV, Müller R, Koehnke J
J Am Chem Soc 140 16641-16649 (2018)
PMID: 30422653

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TipAS antibiotic-recognition domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 26.48 KDa
Source organism: Klebsiella oxytoca
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8KRS7 (Residues: 1-217; Coverage: 98%)
Gene name: albA
Sequence domains: TipAS antibiotic-recognition domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P43212
Unit cell:
a: 69.922Å b: 69.922Å c: 95.225Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Exploring antibiotic resistance with chemical tools.
Velema WA. (2023)
1 more