› 6ha0

X-ray diffraction
1.85Å resolution

Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens

Released:
DOI: 10.2210/pdb6ha0/pdb
PDB entry 6ha0 coloured by chain, front view.
PDB entry 6ha0 coloured by chain, side view.
PDB entry 6ha0 coloured by chain, top view.
Source organism: Rotavirus A
Primary publication:
Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens.
Gozalbo-Rovira R, Ciges-Tomas JR, Vila-Vicent S, Buesa J, Santiso-Bellón C, Monedero V, Yebra MJ, Marina A, Rodríguez-Díaz J
PLoS Pathog 15 e1007865 (2019)
PMID: 31226167

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Outer capsid protein VP4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.55 KDa
Source organism: Rotavirus A
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0S0VKY7 (Residues: 2-160; Coverage: 90%)
Gene name: VP4
Sequence domains: Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 38.739Å b: 54.641Å c: 67.944Å
α: 90° β: 97.73° γ: 90°
R-values:
R R work R free
0.179 0.176 0.233
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The Impact of Human Genetic Polymorphisms on Rotavirus Susceptibility, Epidemiology, and Vaccine Take.
Sharma et al. (2020)
9 more

3 mentions without citation

Structural Basis of Glycan Recognition of Rotavirus.
Sun et al. (2021)
2 more