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› 6hb4

X-ray diffraction
3.05Å resolution

TFAM in Complex with Site-Y

Released:
DOI: 10.2210/pdb6hb4/pdb
Model geometry
Fit model/data
PDB entry 6hb4 coloured by chain, front view.
PDB entry 6hb4 coloured by chain, side view.
PDB entry 6hb4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Cuppari A, Fernández-Millán P, Battistini F, Tarrés-Solé A, Lyonnais S, Iruela G, Ruiz-López E, Enciso Y, Rubio-Cosials A, Prohens R, Pons M, Alfonso C, Tóth K, Rivas G, Orozco M, Solà M
OpenAccess logo Nucleic Acids Res 47 6519-6537 (2019)
PMID: 31114891

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-119989 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Transcription factor A, mitochondrial Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 213 amino acids
Theoretical weight: 25.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00059 (Residues: 42-246; Coverage: 83%)
Gene names: TCF6, TCF6L2, TFAM
Sequence domains:
DNA (5'*CP*TP*GP*TP*GP*CP*AP*GP*AP*CP*AP*TP*TP*CP*AP*AP*TP*TP*GP*TP*TP*A)-3') Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 22 nucleotides
Theoretical weight: 6.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*TP*AP*AP*CP*AP*AP*TP*TP*GP*AP*AP*TP*GP*TP*CP*TP*GP*CP*AP*CP*AP*G)-3') Chains: C, F, I, L

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand 1PE 4 x 1PE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 157.669Å b: 140.622Å c: 108.919Å
α: 90° β: 130.73° γ: 90°
R-values:
R R work R free
0.192 0.19 0.236
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Interactions of Mitochondrial Transcription Factor A with DNA Damage: Mechanistic Insights and Functional Implications.
Chew et al. (2021)
9 other articles

2 mentions without citation

DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Cuppari et al. (2019)
1 more