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› 6hb8

X-ray diffraction
1.86Å resolution

Crystal structure of OXA-517 beta-lactamase

Released:
DOI: 10.2210/pdb6hb8/pdb
Model geometry
Fit model/data
PDB entry 6hb8 coloured by chain, front view.
PDB entry 6hb8 coloured by chain, side view.
PDB entry 6hb8 coloured by chain, top view.
Source organism: Klebsiella pneumoniae
Entry authors: Raczynska JE, Dabos L, Zavala A, Retailleau P, Iorga B, Jaskolski M, Naas T

Function and Biology Details

Reaction catalysed: 
a beta-lactam + H2O = a substituted beta-amino acid.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 254 amino acids
Theoretical weight: 29.64 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A1U8YI81 (Residues: 21-263; Coverage: 100%)
Gene name: blaOXA
Sequence domains: Penicillin binding protein transpeptidase domain

Ligands and Environments

5 bound ligands:
Ligand SO4 11 x SO4
Ligand ETX 1 x ETX
Ligand GOL 10 x GOL
Ligand CL 2 x CL
Ligand EDO 2 x EDO
1 modified residue:
Ligand KCX 4 x KCX

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P21
Unit cell:
a: 49.8Å b: 125.046Å c: 82.656Å
α: 90° β: 94.65° γ: 90°
R-values:
R R work R free
0.172 0.17 0.219
Expression system: Escherichia coli BL21(DE3)

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