› 6hc3

X-ray diffraction
3.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-119990 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Transcription factor A, mitochondrial Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 224 amino acids
Theoretical weight: 26.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00059 (Residues: 34-246; Coverage: 87%)
Gene names: TCF6, TCF6L2, TFAM
Sequence domains:
DNA/RNA (5'-D(*TP*AP*AP*CP*AP*AP*AP*AP*AP*AP*TP*TP*TP*CP*CP*AP*CP*CP*AP*AP*AP*C)-3') Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 22 nucleotides
Theoretical weight: 6.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*TP*TP*TP*GP*GP*TP*GP*GP*AP*AP*AP*TP*TP*TP*TP*TP*TP*GP*TP*TP*AP*G)-3') Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 22 nucleotides
Theoretical weight: 6.83 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand TLA 5 x TLA
Ligand 1PE 4 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 164.79Å b: 145.136Å c: 108.119Å
α: 90° β: 130.83° γ: 90°
R-values:
R R work R free
0.19 0.188 0.229
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Interactions of Mitochondrial Transcription Factor A with DNA Damage: Mechanistic Insights and Functional Implications.
Chew et al. (2021)
9 other articles

1 mention without citation

DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Cuppari et al. (2019)