› 6hcy

Electron Microscopy
3.1Å resolution

human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.

Released:
DOI: 10.2210/pdb6hcy/pdb
PDB entry 6hcy coloured by chain, front view.
PDB entry 6hcy coloured by chain, side view.
PDB entry 6hcy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Förster F, Mattevi A, Gros P
Nat Commun 9 4337 (2018)
PMID: 30337524
Related structures: EMD-0199

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metalloreductase STEAP4 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 459 amino acids
Theoretical weight: 52.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q687X5 (Residues: 1-459; Coverage: 100%)
Gene names: STAMP2, STEAP4, TNFAIP9
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand NAP 3 x NAP
Ligand HEM 3 x HEM
Ligand FAD 3 x FAD
Ligand NAG 3 x NAG
Ligand 44E 3 x 44E
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-0199
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Combining high throughput and high quality for cryo-electron microscopy data collection.
Weis et al. (2020)
6 more

7 mentions without citation

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Oosterheert et al. (2018)
6 more