› 6hcz

X-ray diffraction
2.3Å resolution

Sjoegren syndrome/scleroderma autoantigen 1 (SSSCA1)

Released:
DOI: 10.2210/pdb6hcz/pdb
PDB entry 6hcz coloured by chain, front view.
PDB entry 6hcz coloured by chain, side view.
PDB entry 6hcz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP
Commun Biol 3 123 (2020)
PMID: 32170109

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129916 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ZNRD2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 21.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: O60232 (Residues: 1-199; Coverage: 100%)
Gene names: SSSCA1, ZNRD2
Sequence domains: Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)

Ligands and Environments

2 bound ligands:
Ligand FMT 1 x FMT
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P43212
Unit cell:
a: 49.49Å b: 49.49Å c: 164.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.26
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

4 citation in other articles

Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Simanov et al. (2021)
3 more

3 mentions without citation

Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Perdreau-Dahl et al. (2020)
2 more