› 6hdu

X-ray diffraction
1.79Å resolution

Crystal structure of human Rab38 in complex with GTP

Released:
DOI: 10.2210/pdb6hdu/pdb
PDB entry 6hdu coloured by chain, front view.
PDB entry 6hdu coloured by chain, side view.
PDB entry 6hdu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.
McGrath E, Waschbüsch D, Baker BM, Khan AR
Small GTPases 12 133-146 (2021)
PMID: 31552791

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-38 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 184 amino acids
Theoretical weight: 20.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P57729 (Residues: 1-181; Coverage: 86%)
Gene name: RAB38
Sequence domains: Ras family

Ligands and Environments

2 bound ligands:
Ligand GTP 4 x GTP
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P21
Unit cell:
a: 70.045Å b: 70.993Å c: 74.487Å
α: 90° β: 102.21° γ: 90°
R-values:
R R work R free
0.19 0.188 0.212
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System.
Kuwahara et al. (2020)
9 more

2 mentions without citation

Structural analysis of the full-length human LRRK2.
Myasnikov et al. (2021)
1 more