6hg9

X-ray diffraction
3.62Å resolution

Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-185451 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-17F Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96PD4 (Residues: 31-163; Coverage: 100%)
Gene name: IL17F
Sequence domains: Interleukin-17
Interleukin-17 receptor C Chain: B
Molecule details ›
Chain: B
Length: 451 amino acids
Theoretical weight: 50.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NAC3 (Residues: 95-538; Coverage: 58%)
Gene names: IL17RC, UNQ6118/PRO20040/PRO38901
Sequence domains: Interleukin-17 receptor extracellular region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R32
Unit cell:
a: 160.312Å b: 160.312Å c: 197.983Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.226 0.258
Expression system: Homo sapiens