› 6hga

X-ray diffraction
2.6Å resolution

Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab

Released:
DOI: 10.2210/pdb6hga/pdb
PDB entry 6hga coloured by chain, front view.
PDB entry 6hga coloured by chain, side view.
PDB entry 6hga coloured by chain, top view.
Source organisms:
Primary publication:
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Goepfert A, Lehmann S, Blank J, Kolbinger F, Rondeau JM
Immunity 52 499-512.e5 (2020)
PMID: 32187518

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212623 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-17 receptor C Chain: B
Molecule details ›
Chain: B
Length: 264 amino acids
Theoretical weight: 29.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NAC3 (Residues: 279-538; Coverage: 34%)
Gene names: IL17RC, UNQ6118/PRO20040/PRO38901
Sequence domains: Interleukin-17 receptor extracellular region
anti-APP-tag Fab heavy-chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
Expression system: Mus musculus
anti-APP-tag Fab light-chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.15 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6222
Unit cell:
a: 250.91Å b: 250.91Å c: 78.61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.205 0.232
Expression systems:
  • Homo sapiens
  • Mus musculus

Quick links

Citations

19 review citations

The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside.
Liu et al. (2020)
18 more

1 mention without citation

IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Goepfert et al. (2022)