› 6hh2

X-ray diffraction
1.45Å resolution

Rab29 small GTPase bound to GDP

Released:
DOI: 10.2210/pdb6hh2/pdb
PDB entry 6hh2 coloured by chain, front view.
PDB entry 6hh2 coloured by chain, side view.
PDB entry 6hh2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.
McGrath E, Waschbüsch D, Baker BM, Khan AR
Small GTPases 12 133-146 (2021)
PMID: 31552791

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-7L1 Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14966 (Residues: 1-177; Coverage: 87%)
Gene names: RAB29, RAB7L1
Sequence domains: Ras family

Ligands and Environments

2 bound ligands:
Ligand GDP 1 x GDP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P3121
Unit cell:
a: 71.96Å b: 71.96Å c: 86.348Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.165 0.184
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System.
Kuwahara et al. (2020)
9 more

2 mentions without citation

LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.
McGrath et al. (2021)
1 more