› 6hil

X-ray diffraction
2.3Å resolution

X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy

Released:
DOI: 10.2210/pdb6hil/pdb
PDB entry 6hil coloured by chain, front view.
PDB entry 6hil coloured by chain, side view.
PDB entry 6hil coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy.
Bokhovchuk F, Mesrouze Y, Izaac A, Meyerhofer M, Zimmermann C, Fontana P, Schmelzle T, Erdmann D, Furet P, Kallen J, Chène P
FEBS J 286 2381-2398 (2019)
PMID: 30903741

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151214 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 218 amino acids
Theoretical weight: 25.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28347 (Residues: 208-425; Coverage: 51%)
Gene names: TCF13, TEAD1, TEF1
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1
Transcriptional coactivator YAP1 Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 41 amino acids
Theoretical weight: 4.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46937 (Residues: 60-100; Coverage: 8%)
Gene names: YAP1, YAP65

Ligands and Environments

1 bound ligand:
Ligand MYR 4 x MYR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 40.125Å b: 46.544Å c: 144.337Å
α: 98.61° β: 90.85° γ: 108.14°
R-values:
R R work R free
0.244 0.242 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Regulation of TEAD Transcription Factors in Cancer Biology.
Huh et al. (2019)
5 more

1 mention without citation

Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy.
Bokhovchuk et al. (2019)