› 6hiq

Electron Microscopy
3.2Å resolution

Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation

Released:
DOI: 10.2210/pdb6hiq/pdb
PDB entry 6hiq coloured by chain, front view.
PDB entry 6hiq coloured by chain, side view.
PDB entry 6hiq coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Conformational transitions of the serotonin 5-HT3 receptor.
Polovinkin L, Hassaine G, Perot J, Neumann E, Jensen AA, Lefebvre SN, Corringer PJ, Neyton J, Chipot C, Dehez F, Schoehn G, Nury H
Nature 563 275-279 (2018)
PMID: 30401839
Related structures: EMD-0227

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
5-hydroxytryptamine receptor 3A Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 452 amino acids
Theoretical weight: 52.17 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P23979 (Residues: 36-303, 305-487; Coverage: 97%)
Gene names: 5ht3, Htr3, Htr3a
Sequence domains:
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 5 x NAG
Ligand SRO 5 x SRO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-0227
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Progress in nicotinic receptor structural biology.
Gharpure et al. (2020)
12 more

7 mentions without citation

Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges.
Sarkar et al. (2020)
6 more