› 6hmc

X-ray diffraction
1.03Å resolution

STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 gene product) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27

Released:
DOI: 10.2210/pdb6hmc/pdb
PDB entry 6hmc coloured by chain, front view.
PDB entry 6hmc coloured by chain, side view.
PDB entry 6hmc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures.
Lindenblatt D, Nickelsen A, Applegate VM, Hochscherf J, Witulski B, Bouaziz Z, Marminon C, Bretner M, Le Borgne M, Jose J, Niefind K
ACS Omega 4 5471-5478 (2019)
PMID: 31559376

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148708 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha' Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19784 (Residues: 1-350; Coverage: 100%)
Gene names: CK2A2, CSNK2A2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 8 x EDO
Ligand FXB 1 x FXB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P1
Unit cell:
a: 46.3Å b: 47.3Å c: 50.32Å
α: 113.44° β: 90.38° γ: 90.67°
R-values:
R R work R free
0.123 0.123 0.136
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor.
El-Awaad et al. (2021)
5 more