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› 6hmo

Solution NMR

Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier

Released:
DOI: 10.2210/pdb6hmo/pdb
PDB entry 6hmo coloured by chain, ensemble of 20 models, front view.
PDB entry 6hmo coloured by chain, ensemble of 20 models, side view.
PDB entry 6hmo coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of a small molecule targeting RNA for a specific splicing correction.
Campagne S, Boigner S, Rüdisser S, Moursy A, Gillioz L, Knörlein A, Hall J, Ratni H, Cléry A, Allain FH
Nat Chem Biol 15 1191-1198 (2019)
PMID: 31636429

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197094 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: synthetic construct
RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.55 KDa
Source organism: Homo sapiens
Expression system: synthetic construct

Ligands and Environments

1 bound ligand:
Ligand GDZ 1 x GDZ
1 modified residue:
Ligand PSU 2 x PSU

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 75%
Refinement method: simulated annealing
Expression system: synthetic construct

Quick links

Citations

25 review citations

Targeting RNA with small molecules: from fundamental principles towards the clinic.
Falese et al. (2021)
24 more

4 mentions without citation

Targeting RNA structures with small molecules.
Childs-Disney et al. (2022)
3 more