› 6hpy

X-ray diffraction
2Å resolution

Crystal structure of ENL (MLLT1) in complex with compound 12

Released:
DOI: 10.2210/pdb6hpy/pdb
PDB entry 6hpy coloured by chain, front view.
PDB entry 6hpy coloured by chain, side view.
PDB entry 6hpy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
Heidenreich D, Moustakim M, Schmidt J, Merk D, Brennan PE, Fedorov O, Chaikuad A, Knapp S
J Med Chem 61 10929-10934 (2018)
PMID: 30407816

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ENL Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 18.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03111 (Residues: 1-148; Coverage: 27%)
Gene names: ENL, LTG19, MLLT1, YEATS1
Sequence domains: YEATS family
Structure domains: YEATS domain

Ligands and Environments

3 bound ligands:
Ligand EDO 3 x EDO
Ligand SO4 1 x SO4
Ligand GKN 1 x GKN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P43212
Unit cell:
a: 49.039Å b: 49.039Å c: 132.729Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.26
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Protein lysine crotonylation: past, present, perspective.
Jiang et al. (2021)
2 more