› 6hpz

X-ray diffraction
2.3Å resolution

Crystal structure of ENL (MLLT1) in complex with acetyllysine

Released:
DOI: 10.2210/pdb6hpz/pdb
PDB entry 6hpz coloured by chain, front view.
PDB entry 6hpz coloured by chain, side view.
PDB entry 6hpz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
Heidenreich D, Moustakim M, Schmidt J, Merk D, Brennan PE, Fedorov O, Chaikuad A, Knapp S
J Med Chem 61 10929-10934 (2018)
PMID: 30407816

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ENL Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 18.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03111 (Residues: 1-148; Coverage: 27%)
Gene names: ENL, LTG19, MLLT1, YEATS1
Sequence domains: YEATS family
Structure domains: YEATS domain

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand ALY 1 x ALY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 49.31Å b: 49.31Å c: 129.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.232 0.296
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Protein lysine crotonylation: past, present, perspective.
Jiang et al. (2021)
2 more

1 mention without citation

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.
Ni et al. (2019)