› 6hr2

X-ray diffraction
1.76Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-154077 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Transcription activator BRG1 Chains: A, E
Molecule details ›
Chains: A, E
Length: 120 amino acids
Theoretical weight: 14.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51532 (Residues: 1449-1568; Coverage: 7%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains: Bromodomain
von Hippel-Lindau disease tumor suppressor Chains: B, F
Molecule details ›
Chains: B, F
Length: 149 amino acids
Theoretical weight: 17.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P40337 (Residues: 61-209; Coverage: 70%)
Gene name: VHL
Sequence domains:
Elongin-C Chains: C, G
Molecule details ›
Chains: C, G
Length: 97 amino acids
Theoretical weight: 10.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Gene names: ELOC, TCEB1
Sequence domains: Skp1 family, tetramerisation domain
Elongin-B Chains: D, H
Molecule details ›
Chains: D, H
Length: 104 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15370 (Residues: 1-104; Coverage: 88%)
Gene names: ELOB, TCEB2
Sequence domains: Ubiquitin family

Ligands and Environments

3 bound ligands:
Ligand FWZ 2 x FWZ
Ligand DMS 2 x DMS
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 60.332Å b: 61.678Å c: 81.603Å
α: 69.43° β: 83.38° γ: 86.42°
R-values:
R R work R free
0.216 0.216 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

77 review citations

PROTAC targeted protein degraders: the past is prologue.
Békés et al. (2022)
76 more

7 mentions without citation

Advancing targeted protein degradation for cancer therapy.
Dale et al. (2021)
6 more