› 6hre

Electron Microscopy
3.2Å resolution

Paired helical filament from sporadic Alzheimer's disease brain

Released:
DOI: 10.2210/pdb6hre/pdb
PDB entry 6hre coloured by chain, front view.
PDB entry 6hre coloured by chain, side view.
PDB entry 6hre coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Falcon B, Zhang W, Schweighauser M, Murzin AG, Vidal R, Garringer HJ, Ghetti B, Scheres SHW, Goedert M
Acta Neuropathol 136 699-708 (2018)
PMID: 30276465
Related structures: EMD-0259

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-0259

Quick links

Citations

44 review citations

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy.
Colin et al. (2020)
43 more

19 mentions without citation

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
Oakley et al. (2020)
18 more