› 6hvc

Solution NMR

NMR structure of Urotensin Peptide Asp-c[Cys-Phe-Trp-(N-Me)Lys-Tyr-Cys]-Val in SDS solution

Released:
DOI: 10.2210/pdb6hvc/pdb
PDB entry 6hvc coloured by chain, ensemble of 10 models, front view.
PDB entry 6hvc coloured by chain, ensemble of 10 models, side view.
PDB entry 6hvc coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.
Merlino F, Billard É, Yousif AM, Di Maro S, Brancaccio D, Abate L, Carotenuto A, Bellavita R, d'Emmanuele di Villa Bianca R, Santicioli P, Marinelli L, Novellino E, Hébert TE, Lubell WD, Chatenet D, Grieco P
J Med Chem 62 1455-1467 (2019)
PMID: 30615452

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131917 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urotensin-2 Chain: A
Molecule details ›
Chain: A
Length: 8 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O95399 (Residues: 117-124; Coverage: 8%)
Gene names: UNQ525/PRO1068, UTS2
Sequence domains: Urotensin II

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 47%
Refinement method: simulated annealing
Expression system: Not provided

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Citations

2 review citations

Recent advances in the development of therapeutic peptides.
Fetse et al. (2023)
1 more