PDB 6i2k structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.

Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.

NTP + H(2)O = NDP + phosphate

Biochemical function:

structural molecule activity

Biological process:

not assigned

Cellular component:

membrane

Sequence domains:

Structure analysis Details

Assembly composition:

hetero 300-mer (preferred)

Assembly name:

Protease 2A and Lysosome membrane protein 2 (preferred)

PDBe Complex ID:

PDB-CPX-171910 (preferred)

Entry contents:

5 distinct polypeptide molecules

Macromolecules (10 distinct):

Capsid protein VP1 Chain: A

Molecule details ›

Chain: A
Length: 297 amino acids
Theoretical weight: 32.76 KDa
Source organism: Enterovirus A71
UniProt:

Canonical: Q66479 (Residues: 566-862; Coverage: 14%)

Sequence domains: picornavirus capsid protein

Capsid protein VP2 Chain: B

Molecule details ›

Chain: B
Length: 254 amino acids
Theoretical weight: 27.78 KDa
Source organism: Enterovirus A71
UniProt:

Canonical: Q66479 (Residues: 70-323; Coverage: 12%)

Sequence domains: picornavirus capsid protein

Capsid protein VP3 Chain: C

Molecule details ›

Chain: C
Length: 242 amino acids
Theoretical weight: 26.54 KDa
Source organism: Enterovirus A71
UniProt:

Canonical: Q66479 (Residues: 324-565; Coverage: 11%)

Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls

Capsid protein VP4 Chain: D

Molecule details ›

Chain: D
Length: 58 amino acids
Theoretical weight: 6.38 KDa
Source organism: Enterovirus A71
UniProt:

Canonical: Q66479 (Residues: 12-69; Coverage: 3%)

Sequence domains: Picornavirus coat protein (VP4)

Lysosome membrane protein 2 Chain: E

Molecule details ›

Chain: E
Length: 416 amino acids
Theoretical weight: 47.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt: