› 6i3n

Electron Microscopy
3.1Å resolution

Helical MyD88 death domain filament

Released:
DOI: 10.2210/pdb6i3n/pdb
PDB entry 6i3n coloured by chain, front view.
PDB entry 6i3n coloured by chain, side view.
PDB entry 6i3n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
Moncrieffe MC, Bollschweiler D, Li B, Penczek PA, Hopkins L, Bryant CE, Klenerman D, Gay NJ
Structure 28 281-289.e3 (2020)
PMID: 31995744
Related structures: EMD-4405

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tridecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid differentiation primary response protein MyD88 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M
Length: 162 amino acids
Theoretical weight: 17.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99836 (Residues: 1-151; Coverage: 51%)
Gene name: MYD88
Sequence domains: Death domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-4405
Expression system: Escherichia coli

Quick links

Citations

9 review citations

There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling.
Mace et al. (2021)
8 more

2 mentions without citation

Structural and functional understanding of the toll-like receptors.
Asami et al. (2021)
1 more