› 6i3v

X-ray diffraction
1.98Å resolution

x-ray structure of the human mitochondrial PRELID1 in complex with TRIAP1

Released:
DOI: 10.2210/pdb6i3v/pdb
PDB entry 6i3v coloured by chain, front view.
PDB entry 6i3v coloured by chain, side view.
PDB entry 6i3v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Miliara X, Tatsuta T, Berry JL, Rouse SL, Solak K, Chorev DS, Wu D, Robinson CV, Matthews S, Langer T
Nat Commun 10 1130 (2019)
PMID: 30850607

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129078 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PRELI domain-containing protein 1, mitochondrial Chains: B, F
Molecule details ›
Chains: B, F
Length: 182 amino acids
Theoretical weight: 21.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y255 (Residues: 1-173; Coverage: 79%)
Gene names: CGI-106, PRELI, PRELID1, SBBI12
Sequence domains: PRELI-like family
TP53-regulated inhibitor of apoptosis 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 69 amino acids
Theoretical weight: 8.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43715 (Residues: 1-67; Coverage: 88%)
Gene names: 15E1.1, HSPC132, TRIAP1
Sequence domains: Uncharacterised protein family (UPF0203)

Ligands and Environments

3 bound ligands:
Ligand MYR 2 x MYR
Ligand CL 13 x CL
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6322
Unit cell:
a: 127.312Å b: 127.312Å c: 177.39Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.205 0.245
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Mechanisms of nonvesicular lipid transport.
Reinisch et al. (2021)
7 more

1 mention without citation

Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques.
Ali et al. (2023)