› 6i9s

X-ray diffraction
2.48Å resolution

hRobo2 Extracellular Domains 2-3

Released:
DOI: 10.2210/pdb6i9s/pdb
PDB entry 6i9s coloured by chain, front view.
PDB entry 6i9s coloured by chain, side view.
PDB entry 6i9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Principles in Robo Activation and Auto-inhibition.
Barak R, Yom-Tov G, Guez-Haddad J, Gasri-Plotnitsky L, Maimon R, Cohen-Berkman M, McCarthy AA, Perlson E, Henis-Korenblit S, Isupov MN, Opatowsky Y
Cell 177 272-285.e16 (2019)
PMID: 30853216

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Roundabout homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 208 amino acids
Theoretical weight: 23.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HCK4 (Residues: 126-312; Coverage: 14%)
Gene names: KIAA1568, ROBO2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 62.22Å b: 70.52Å c: 97.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.226 0.293
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

New insights into the molecular mechanisms of axon guidance receptor regulation and signaling.
Zang et al. (2021)
6 more