› 6iap

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208156 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Natural cytotoxicity triggering receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O76036 (Residues: 25-206; Coverage: 64%)
Gene names: LY94, NCR1
Sequence domains: Immunoglobulin domain
Fab NKp46-4 light chain Chain: D
Molecule details ›
Chain: D
Length: 211 amino acids
Theoretical weight: 23.06 KDa
Source organism: synthetic construct
Expression system: Cricetulus griseus
Fab NKp46-4 heavy chain Chain: E
Molecule details ›
Chain: E
Length: 217 amino acids
Theoretical weight: 23.19 KDa
Source organism: synthetic construct
Expression system: Cricetulus griseus
Fab NKp46-1 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.52 KDa
Source organism: synthetic construct
Expression system: Cricetulus griseus
Fab NKp46-1 light chain Chain: L
Molecule details ›
Chain: L
Length: 211 amino acids
Theoretical weight: 23.24 KDa
Source organism: synthetic construct
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21
Unit cell:
a: 67.858Å b: 73.827Å c: 128.518Å
α: 90° β: 90.57° γ: 90°
R-values:
R R work R free
0.191 0.187 0.263
Expression systems:
  • Spodoptera frugiperda
  • Cricetulus griseus

Quick links

Citations

119 review citations

NK cells for cancer immunotherapy.
Shimasaki et al. (2020)
118 more