› 6ip9

X-ray diffraction
1.85Å resolution

Crystal Structure of Lanthanum ion (La3+) bound bovine alpha-lactalbumin

Released:
DOI: 10.2210/pdb6ip9/pdb
PDB entry 6ip9 coloured by chain, front view.
PDB entry 6ip9 coloured by chain, side view.
PDB entry 6ip9 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Cytotoxicity of apo bovine α-lactalbumin complexed with La3+ on cancer cells supported by its high resolution crystal structure.
Yarramala DS, Prakash P, Ranade DS, Doshi S, Kulkarni PP, Bhaumik P, Rao CP
Sci Rep 9 1780 (2019)
PMID: 30741951

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132933 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-lactalbumin Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.2 KDa
Source organism: Bos taurus
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: P00711 (Residues: 20-142; Coverage: 100%)
Gene names: ALACTA, LALBA
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
Ligand LA 1 x LA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P3121
Unit cell:
a: 47.45Å b: 47.45Å c: 89.84Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.197 0.216
Expression system: Enterobacteria phage L1

Quick links

Citations

2 review citations

Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs.
Yi et al. (2021)
1 more

1 mention without citation

Cytotoxicity of apo bovine α-lactalbumin complexed with La3+ on cancer cells supported by its high resolution crystal structure.
Yarramala et al. (2019)