› 6irh

Electron Microscopy
7.8Å resolution

Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III

Released:
DOI: 10.2210/pdb6irh/pdb
PDB entry 6irh coloured by chain, front view.
PDB entry 6irh coloured by chain, side view.
PDB entry 6irh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors.
Zhang JB, Chang S, Xu P, Miao M, Wu H, Zhang Y, Zhang T, Wang H, Zhang J, Xie C, Song N, Luo C, Zhang X, Zhu S
Cell Rep 25 3582-3590.e4 (2018)
PMID: 30590034
Related structures: EMD-9717

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170224 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 847 amino acids
Theoretical weight: 95.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2A Chains: B, D
Molecule details ›
Chains: B, D
Length: 841 amino acids
Theoretical weight: 94.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12879 (Residues: 1-841; Coverage: 57%)
Gene names: GRIN2A, NMDAR2A
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.8Å
Relevant EMDB volumes: EMD-9717
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
7 more

1 mention without citation

Glutamate's Effects on the N-Methyl-D-Aspartate (NMDA) Receptor Ion Channel in Alzheimer's Disease Brain: Challenges for PET Radiotracer Development for Imaging the NMDA Ion Channel.
Shah et al. (2023)