› 6irs

Electron Microscopy
3.3Å resolution

human LAT1-4F2hc complex incubated with JPH203

Released:
DOI: 10.2210/pdb6irs/pdb
PDB entry 6irs coloured by chain, front view.
PDB entry 6irs coloured by chain, side view.
PDB entry 6irs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.
Yan R, Zhao X, Lei J, Zhou Q
Nature 568 127-130 (2019)
PMID: 30867591
Related structures: EMD-9721

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140015 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Amino acid transporter heavy chain SLC3A2 Chain: A
Molecule details ›
Chain: A
Length: 647 amino acids
Theoretical weight: 70.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08195 (Residues: 2-67, 68-630; Coverage: 100%)
Gene names: MDU1, SLC3A2
Sequence domains:
Large neutral amino acids transporter small subunit 1 Chain: B
Molecule details ›
Chain: B
Length: 527 amino acids
Theoretical weight: 57.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01650 (Residues: 2-507; Coverage: 100%)
Gene names: CD98LC, LAT1, MPE16, SLC7A5
Sequence domains: Amino acid permease

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand 3PH 2 x 3PH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-9721
Expression system: Homo sapiens

Quick links

Citations

36 review citations

A Historical Review of Brain Drug Delivery.
Pardridge WM. (2022)
35 more

20 mentions without citation

Rush Hour of LATs towards Their Transport Cycle.
Nicolàs-Aragó et al. (2021)
19 more