› 6isb

X-ray diffraction
2.5Å resolution

crystal structure of human CD226

Released:
DOI: 10.2210/pdb6isb/pdb
PDB entry 6isb coloured by chain, front view.
PDB entry 6isb coloured by chain, side view.
PDB entry 6isb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Wang H, Qi J, Zhang S, Li Y, Tan S, Gao GF
Proc Natl Acad Sci U S A 116 988-996 (2019)
PMID: 30591568

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD226 antigen Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 232 amino acids
Theoretical weight: 26.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: Q15762 (Residues: 19-250; Coverage: 73%)
Gene names: CD226, DNAM1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 57.879Å b: 118.492Å c: 123.171Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.255 0.267
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4

Quick links

Citations

4 review citations

TIGIT/CD226 Axis Regulates Anti-Tumor Immunity.
Yeo et al. (2021)
3 more

1 mention without citation

Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Wang et al. (2019)