› 6itv

X-ray diffraction
1.88Å resolution

Crystal structure of activated c-KIT in complex with compound

Released:
DOI: 10.2210/pdb6itv/pdb
PDB entry 6itv coloured by chain, front view.
PDB entry 6itv coloured by chain, side view.
PDB entry 6itv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wu TS, Wu SY

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.75 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P10721 (Residues: 547-693, 754-935; Coverage: 35%)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand AWO 1 x AWO
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: P43212
Unit cell:
a: 59.853Å b: 59.853Å c: 197.984Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.18 0.231
Expression system: unidentified baculovirus

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