Protein Data Bank in Europe

Chain: A
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

• Canonical: Q92542 (Residues: 1-709; Coverage: 100%)

Gene names: KIAA0253, NCSTN, UNQ1874/PRO4317
Sequence domains:

• Nicastrin small lobe
• Nicastrin

Chain: B
Length: 467 amino acids
Theoretical weight: 52.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

• Canonical: P49768 (Residues: 1-467; Coverage: 100%)

Gene names: AD3, PS1, PSEN1, PSNL1
Sequence domains: Presenilin

Chain: C
Length: 265 amino acids
Theoretical weight: 29.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

• Canonical: Q96BI3 (Residues: 1-265; Coverage: 100%)

Gene names: APH1A, CGI-78, PSF, UNQ579/PRO1141
Sequence domains: Aph-1 protein

Chain: D
Length: 101 amino acids
Theoretical weight: 12.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

• Canonical: Q9NZ42 (Residues: 1-101; Coverage: 100%)

Gene names: MDS033, PEN2, PSENEN
Sequence domains: Presenilin enhancer-2 subunit of gamma secretase

Chain: E
Length: 104 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

• Canonical: P05067 (Residues: 688-770; Coverage: 11%)

Gene names: A4, AD1, APP
Sequence domains:

• Beta-amyloid peptide (beta-APP)
• Beta-amyloid precursor protein C-terminus