› 6jbt

X-ray diffraction
2.47Å resolution

Complex structure of toripalimab-Fab and PD-1

Released:
DOI: 10.2210/pdb6jbt/pdb
Model geometry
Fit model/data
PDB entry 6jbt coloured by chain, front view.
PDB entry 6jbt coloured by chain, side view.
PDB entry 6jbt coloured by chain, top view.
Source organisms:
Primary publication:
Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Liu H, Guo L, Zhang J, Zhou Y, Zhou J, Yao J, Wu H, Yao S, Chen B, Chai Y, Qi J, Gao GF, Tan S, Feng H, Yan J
OpenAccess logo MAbs 11 681-690 (2019)
PMID: 30892132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212037 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Programmed cell death protein 1 Chain: F
Molecule details ›
Chain: F
Length: 157 amino acids
Theoretical weight: 17.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15116 (Residues: 21-170; Coverage: 55%)
Gene names: PD1, PDCD1
Sequence domains: Immunoglobulin V-set domain
Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 23.97 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
Light chain Chain: L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 75.768Å b: 64.197Å c: 78.722Å
α: 90° β: 113.36° γ: 90°
R-values:
R R work R free
0.203 0.2 0.252
Expression systems:
  • Homo sapiens
  • Cricetulus griseus

Quick links

Citations

8 review citations

Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist?
Vivaldi et al. (2020)
7 more

8 mentions without citation

Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China.
Zhang et al. (2021)
7 more