› 6jjn

X-ray diffraction
2.5Å resolution

Crystal structure of Mumps virus hemagglutinin-neuraminidase bound to sialyl lewisX

Released:
DOI: 10.2210/pdb6jjn/pdb
PDB entry 6jjn coloured by chain, front view.
PDB entry 6jjn coloured by chain, side view.
PDB entry 6jjn coloured by chain, top view.
Source organism: Mumps orthorubulavirus
Primary publication:
Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus.
Kubota M, Matsuoka R, Suzuki T, Yonekura K, Yanagi Y, Hashiguchi T
J Virol 93 (2019)
PMID: 31118251

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
HN protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 489 amino acids
Theoretical weight: 54.27 KDa
Source organism: Mumps orthorubulavirus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9WAF5 (Residues: 106-582; Coverage: 82%)
Gene name: HN
Sequence domains: Haemagglutinin-neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, GAL, SIA, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 4 x NAG
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P61
Unit cell:
a: 137.417Å b: 137.417Å c: 177.807Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.205
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Mumps Orchitis: Clinical Aspects and Mechanisms.
Wu et al. (2021)
4 more

1 mention without citation

Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus.
Kubota et al. (2019)