› 6jxr

Electron Microscopy
3.7Å resolution

Structure of human T cell receptor-CD3 complex

Released:
DOI: 10.2210/pdb6jxr/pdb
PDB entry 6jxr coloured by chain, front view.
PDB entry 6jxr coloured by chain, side view.
PDB entry 6jxr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of assembly of the human T cell receptor-CD3 complex.
Zheng L, Lin J, Zhang B, Zhu Y, Li N, Xie S, Wang Y, Gao N, Huang Z
Nature 573 546-552 (2019)
PMID: 31461748
Related structures: EMD-9895

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-100921 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
T-cell surface glycoprotein CD3 zeta chain Chains: a, b
Molecule details ›
Chains: a, b
Length: 164 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20963 (Residues: 1-164; Coverage: 100%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Sequence domains:
T-cell surface glycoprotein CD3 delta chain Chain: d
Molecule details ›
Chain: d
Length: 171 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04234 (Residues: 1-171; Coverage: 100%)
Gene names: CD3D, T3D
Sequence domains:
T-cell surface glycoprotein CD3 epsilon chain Chains: e, f
Molecule details ›
Chains: e, f
Length: 207 amino acids
Theoretical weight: 23.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07766 (Residues: 1-207; Coverage: 100%)
Gene names: CD3E, T3E
Sequence domains:
T-cell surface glycoprotein CD3 gamma chain Chain: g
Molecule details ›
Chain: g
Length: 182 amino acids
Theoretical weight: 20.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09693 (Residues: 1-182; Coverage: 100%)
Gene names: CD3G, T3G
Sequence domains:
Possible J 11 gene segment; T cell receptor alpha chain constant; T cell receptor alpha variable 12-3 Chain: m
Molecule details ›
Chain: m
Length: 252 amino acids
Theoretical weight: 28.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0B4J271 (Residues: 22-114; Coverage: 100%)
  • Canonical: A0N4Z6 (Residues: 4-20; Coverage: 85%)
  • Canonical: P01848 (Residues: 1-140; Coverage: 100%)
Gene names: TCRA, TRAC, TRAV12-3, Tcr-alpha
Sequence domains:
M1-specific T cell receptor beta chain; T cell receptor beta variable 6-5 Chain: n
Molecule details ›
Chain: n
Length: 291 amino acids
Theoretical weight: 32.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0K0K1A5 (Residues: 22-112; Coverage: 98%)
  • Canonical: P0DSE2 (Residues: 119-310; Coverage: 66%)
Gene names: TRB, TRBV6-5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-9895
Expression system: Homo sapiens

Quick links

Citations

36 review citations

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis.
Marchini et al. (2021)
35 more

31 mentions without citation

50 Years of structural immunology.
Wilson et al. (2021)
30 more