› 6jym

X-ray diffraction
1.5Å resolution

Crystal structure of Prolyl Endopeptidase from Haliotis discus hannai

Released:
DOI: 10.2210/pdb6jym/pdb
PDB entry 6jym coloured by chain, front view.
PDB entry 6jym coloured by chain, side view.
PDB entry 6jym coloured by chain, top view.
Source organism: Haliotis discus hannai
Primary publication:
Characterization and crystal structure of prolyl endopeptidase from abalone (Haliotis discus hannai).
Li WY, Li Y, Chen YL, Hu JJ, Mengist HM, Liu GM, Jin T, Cao MJ
Food Chem 333 127452 (2020)
PMID: 32673951

Function and Biology Details

Reaction catalysed: 
Hydrolysis of --Pro-|- and to a lesser extent --Ala-|- in oligopeptides.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prolyl endopeptidase Chain: A
Molecule details ›
Chain: A
Length: 758 amino acids
Theoretical weight: 85.88 KDa
Source organism: Haliotis discus hannai
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: A0A1X9T5X9 (Residues: 1-706; Coverage: 100%)
Gene name: PREP
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 55.325Å b: 104.955Å c: 137.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.179 0.192
Expression system: Escherichia coli K-12

Quick links

Citations

1 citations in other articles

Crystal Structure of Inhibitor-Bound Bacterial Oligopeptidase B in the Closed State: Similarity and Difference between Protozoan and Bacterial Enzymes.
Petrenko et al. (2023)

1 mention without citation

Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications.
Baharin et al. (2022)