› 6k4j

X-ray diffraction
2.7Å resolution

Crystal Structure of the the CD9

Released:
DOI: 10.2210/pdb6k4j/pdb
PDB entry 6k4j coloured by chain, front view.
PDB entry 6k4j coloured by chain, side view.
PDB entry 6k4j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into tetraspanin CD9 function.
Umeda R, Satouh Y, Takemoto M, Nakada-Nakura Y, Liu K, Yokoyama T, Shirouzu M, Iwata S, Nomura N, Sato K, Ikawa M, Nishizawa T, Nureki O
Nat Commun 11 1606 (2020)
PMID: 32231207

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD9 antigen Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21926 (Residues: 1-228; Coverage: 98%)
Gene names: CD9, GIG2, MIC3, TSPAN29
Sequence domains: Tetraspanin family

Ligands and Environments

3 bound ligands:
Ligand PLM 1 x PLM
Ligand OLC 1 x OLC
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2221
Unit cell:
a: 45.18Å b: 125.21Å c: 129.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.262 0.289
Expression system: Spodoptera frugiperda

Quick links

Citations

24 review citations

Find and fuse: Unsolved mysteries in sperm-egg recognition.
Bianchi et al. (2020)
23 more

10 mentions without citation

Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential.
Harrison et al. (2021)
9 more