› 6k9y

X-ray diffraction
2.2Å resolution

Crystal structure of human VAT-1

Released:
DOI: 10.2210/pdb6k9y/pdb
PDB entry 6k9y coloured by chain, front view.
PDB entry 6k9y coloured by chain, side view.
PDB entry 6k9y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for interorganelle phospholipid transport mediated by VAT-1.
Watanabe Y, Tamura Y, Kakuta C, Watanabe S, Endo T
J Biol Chem 295 3257-3268 (2020)
PMID: 32005660

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptic vesicle membrane protein VAT-1 homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 357 amino acids
Theoretical weight: 38.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99536 (Residues: 41-393; Coverage: 90%)
Gene name: VAT1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NO3 8 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P212121
Unit cell:
a: 67.155Å b: 131.72Å c: 174.027Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.255
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Kim et al. (2022)

1 mention without citation

Structural basis for interorganelle phospholipid transport mediated by VAT-1.
Watanabe et al. (2020)