› 6kva

X-ray diffraction
2.2Å resolution

Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope

Released:
DOI: 10.2210/pdb6kva/pdb
PDB entry 6kva coloured by chain, front view.
PDB entry 6kva coloured by chain, side view.
PDB entry 6kva coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.
Shi X, Wan Y, Wang N, Xiang J, Wang T, Yang X, Wang J, Dong X, Dong L, Yan L, Li Y, Liu L, Hou S, Zhong Z, Wilson IA, Yang B, Yang G, Lerner RA
Nat Commun 12 2547 (2021)
PMID: 33953162

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210877 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain Chains: H, h
Molecule details ›
Chains: H, h
Length: 227 amino acids
Theoretical weight: 24.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain Chains: L, l
Molecule details ›
Chains: L, l
Length: 222 amino acids
Theoretical weight: 23.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C-X-C chemokine receptor type 2 Chains: B, b
Molecule details ›
Chains: B, b
Length: 11 amino acids
Theoretical weight: 1.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25025 (Residues: 9-19; Coverage: 3%)
Gene names: CXCR2, IL8RB

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 66.685Å b: 96.337Å c: 70.783Å
α: 90° β: 109.86° γ: 90°
R-values:
R R work R free
0.196 0.194 0.234
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

5 citation in other articles

Bioinformatics analysis of copper death gene in diabetic immune infiltration.
Lu et al. (2023)
4 more