› 6kvf

X-ray diffraction
2.79Å resolution

Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope

Released:
DOI: 10.2210/pdb6kvf/pdb
PDB entry 6kvf coloured by chain, front view.
PDB entry 6kvf coloured by chain, side view.
PDB entry 6kvf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.
Shi X, Wan Y, Wang N, Xiang J, Wang T, Yang X, Wang J, Dong X, Dong L, Yan L, Li Y, Liu L, Hou S, Zhong Z, Wilson IA, Yang B, Yang G, Lerner RA
Nat Commun 12 2547 (2021)
PMID: 33953162

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210878 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 227 amino acids
Theoretical weight: 23.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
light chain Chains: C, L
Molecule details ›
Chains: C, L
Length: 222 amino acids
Theoretical weight: 23.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
C-X-C chemokine receptor type 2 Chains: B, b
Molecule details ›
Chains: B, b
Length: 11 amino acids
Theoretical weight: 1.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25025 (Residues: 9-19; Coverage: 3%)
Gene names: CXCR2, IL8RB

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 159.509Å b: 76.082Å c: 85.364Å
α: 90° β: 108.53° γ: 90°
R-values:
R R work R free
0.23 0.228 0.264
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

4 citation in other articles

Bioinformatics analysis of copper death gene in diabetic immune infiltration.
Lu et al. (2023)
3 more

1 mention without citation

In Silico Maturation of a Nanomolar Antibody against the Human CXCR2.
Buratto et al. (2022)