› 6kzo

Electron Microscopy
3.3Å resolution

membrane protein

Released:
DOI: 10.2210/pdb6kzo/pdb
PDB entry 6kzo coloured by chain, front view.
PDB entry 6kzo coloured by chain, side view.
PDB entry 6kzo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, Pan X, Yan N
Nature 576 492-497 (2019)
PMID: 31766050
Related structures: EMD-0791

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128938 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent T-type calcium channel subunit alpha-1G Chain: A
Molecule details ›
Chain: A
Length: 2261 amino acids
Theoretical weight: 250.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43497 (Residues: 1-2377; Coverage: 95%)
Gene names: CACNA1G, KIAA1123
Sequence domains: Ion transport protein

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand NAG 5 x NAG
Ligand 3PE 13 x 3PE
Ligand Y01 2 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-0791
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Voltage-Gated Ca2+-Channel α1-Subunit de novo Missense Mutations: Gain or Loss of Function - Implications for Potential Therapies.
Striessnig J. (2021)
14 more

11 mentions without citation

P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models.
Tikhonov et al. (2022)
10 more