› 6l3v

Electron Microscopy
2.63Å resolution

The R15G mutant of human Cx31.3/GJC3 connexin hemichannel

Released:
DOI: 10.2210/pdb6l3v/pdb
PDB entry 6l3v coloured by chain, front view.
PDB entry 6l3v coloured by chain, side view.
PDB entry 6l3v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel.
Lee HJ, Jeong H, Hyun J, Ryu B, Park K, Lim HH, Yoo J, Woo JS
Sci Adv 6 eaba4996 (2020)
PMID: 32923625
Related structures: EMD-0827

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction gamma-3 protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 279 amino acids
Theoretical weight: 31.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NFK1 (Residues: 1-279; Coverage: 100%)
Gene names: GJC3, GJE1
Sequence domains: Connexin

Ligands and Environments

1 bound ligand:
Ligand LMN 6 x LMN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.63Å
Relevant EMDB volumes: EMD-0827
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Cellular mechanisms of connexin-based inherited diseases.
Laird et al. (2022)
9 more

1 mention without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)