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› 6l7u

X-ray diffraction
2.24Å resolution

Crystal structure of FKRP in complex with Ba ion, Ba-SAD data

Released:
DOI: 10.2210/pdb6l7u/pdb
Model geometry
Fit model/data
PDB entry 6l7u coloured by chain, front view.
PDB entry 6l7u coloured by chain, side view.
PDB entry 6l7u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.
Kuwabara N, Imae R, Manya H, Tanaka T, Mizuno M, Tsumoto H, Kanagawa M, Kobayashi K, Toda T, Senda T, Endo T, Kato R
OpenAccess logo Nat Commun 11 303 (2020)
PMID: 31949166

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribitol 5-phosphate transferase FKRP Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 455 amino acids
Theoretical weight: 50.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H9S5 (Residues: 45-495; Coverage: 91%)
Gene name: FKRP
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand NAG 5 x NAG
Ligand BA 4 x BA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: P212121
Unit cell:
a: 77.147Å b: 119.241Å c: 255.839Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.234
Expression system: Homo sapiens

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Citations

4 review citations

Dystroglycanopathy: From Elucidation of Molecular and Pathological Mechanisms to Development of Treatment Methods.
Kanagawa M. (2021)
3 more

1 mention without citation

Knowing and combating the enemy: a brief review on SARS-CoV-2 and computational approaches applied to the discovery of drug candidates.
Serafim et al. (2021)