› 6la5

Electron Microscopy
2.86Å resolution

Cryo-EM structure of echovirus 11 complexed with its attaching receptor CD55 at pH 7.4

Released:
DOI: 10.2210/pdb6la5/pdb
PDB entry 6la5 coloured by chain, front view.
PDB entry 6la5 coloured by chain, side view.
PDB entry 6la5 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Niu S, Liu C, Liu C, Liu S, Song Y, Zhang Y, Tian W, Zhao X, Wang P, Gao FG
Chin. Sci. Bull. (2020)
Related structures: EMD-0856

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-102660 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 32.28 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: Q2LJ73 (Residues: 3-287; Coverage: 98%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 251 amino acids
Theoretical weight: 27.97 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: A0A0R5YS56 (Residues: 80-330; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 238 amino acids
Theoretical weight: 26.06 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: A0A346I7K2 (Residues: 332-569; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 69 amino acids
Theoretical weight: 7.5 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: E0WN77 (Residues: 1-69; Coverage: 47%)
Sequence domains: Picornavirus coat protein (VP4)
Complement decay-accelerating factor Chain: E
Molecule details ›
Chain: E
Length: 125 amino acids
Theoretical weight: 13.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08174 (Residues: 161-285; Coverage: 36%)
Gene names: CD55, CR, DAF
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

1 bound ligand:
Ligand SPH 1 x SPH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.86Å
Relevant EMDB volumes: EMD-0856
Expression system: Homo sapiens

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