› 6liu

X-ray diffraction
2.8Å resolution

Crystal structure of apo Tyrosine decarboxylase

Released:
DOI: 10.2210/pdb6liu/pdb
PDB entry 6liu coloured by chain, front view.
PDB entry 6liu coloured by chain, side view.
PDB entry 6liu coloured by chain, top view.
Source organism: Papaver somniferum
Primary publication:
Crystal structures clarify cofactor binding of plant tyrosine decarboxylase.
Wang H, Yu J, Satoh Y, Nakagawa Y, Tanaka R, Kato K, Yao M
Biochem Biophys Res Commun 523 500-505 (2020)
PMID: 31898973

Function and Biology Details

Reactions catalysed: 
L-tyrosine = tyramine + CO(2)
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157101 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine/DOPA decarboxylase 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 531 amino acids
Theoretical weight: 59.42 KDa
Source organism: Papaver somniferum
Expression system: Escherichia coli
UniProt:
  • Canonical: P54769 (Residues: 1-531; Coverage: 100%)
Gene name: TYDC2
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Unit cell:
a: 118.043Å b: 180.864Å c: 217.159Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.242 0.28
Expression system: Escherichia coli

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Citations

3 citation in other articles

Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis.
Wang et al. (2020)
2 more